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Long qt syndrome case study

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These rapid heartbeats might trigger you to suddenly faint. Some people with the condition have seizures. In some severe cases, LQTS can cause sudden death. Some people are born with a genetic mutation that causes long QT syndrome congenital long QT syndrome. Long QT syndrome may be caused by certain medications, mineral imbalances or medical conditions acquired long QT syndrome. Long QT syndrome is treatable.
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Long Qt Syndrome Case Study

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Long QT Syndrome - Harvard Health

It can cause sudden, uncontrollable, dangerous arrhythmias ah-RITH-me-ahs in response to exercise or stress. Arrhythmias are problems with the rate or rhythm of the heartbeat. People who have LQTS also can have arrhythmias for no known reason. However, not everyone who has LQTS has dangerous heart rhythms.
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Hospitalized cancer patients with acquired long QT syndrome-a matched case-control study

In some cases, more than one genetic variant is identified in the same compound heterozygosity or different digenic heterozygosity genes, and subjects with multiple pathogenic mutations may have a more severe disease. Standard-of-care clinical genetic testing for this and other arrhythmia susceptibility syndromes improves the identification of complex genotypes. Therefore, it is important to distinguish between pathogenic mutations and benign rare variants. We identified four genetic variants KCNQ1-p. On the basis of in silico analysis, clinical data from our family, and the evidence from previous studies, we analyzed two mutated channels, KCNQ1-p.
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Aims: The aim of this pilot study was to evaluate provocative sotalol testing to unmask abnormal repolarization due to altered myocardial electrical properties as the key feature in acquired Long-QT-Syndrome. Reliable diagnosis and risk stratification for the individual patient are complicated by the multitude of mechanisms involved in acquired QT-prolongation. The combined influence of all components determines susceptibility to arrhythmias related to QT-prolongation. Methods: Twenty consecutive patients who had experienced torsades de pointes in association with QT-prolonging drugs were tested with i.

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