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Structural Dynamics of α-Actinin-Vinculin Interactions - CORE
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In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. The vinculin gene occurs as a single copy and what appears to be no close relative to take over functions in its absence. Its splice variant metavinculin see below also needs vinculin to heterodimerize and work in a dependent fashion. Vinculin is a kDa cytoskeletal protein with amino acids.