SINGAPORE - The dengue situation in Singapore seems to have eased this year compared with the record spate of cases early last year, but the authorities are urging people to keep their guard up to stamp out mosquito breeding grounds at home to avoid a spike in cases. More than 2, dengue cases have been reported in Singapore so far this year, NEA said on Thursday April 29 in a statement on the launch of the national dengue prevention campaign. In the first six months of last year, 10, dengue infections were reported. NEA said it expects cases to increase towards the middle of the year, with the weather getting warmer. The warmer months of June to October accelerate the development of the Aedes mosquito, and also cause the virus to replicate faster in the insects.
COVID Vaccines: Should We Fear ADE? | The Journal of Infectious Diseases | Oxford Academic
This is unlikely because coronavirus diseases in humans lack the clinical, epidemiological, biological, or pathological attributes of ADE disease exemplified by dengue viruses DENV. Severe disease centers on older persons with preexisting conditions and not infants or individuals with previous coronavirus infections. Live virus challenge of animals given SARS or MERS vaccines resulted in vaccine hypersensitivity reactions VAH , similar to those in humans given inactivated measles or respiratory syncytial virus vaccines. Not since pandemic smallpox or the influenza have humans confronted an epidemic viral pathogen as successful as severe acute respiratory syndrome coronavirus 2 SAR- CoV-2 , a member of a family of viruses that cause serious diseases in many vertebrates [ 1 ].
New and Underused Vaccines
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Dengue is spread by several species of female mosquitoes of the Aedes genus , principally Aedes aegypti. A vaccine for dengue fever has been approved and is commercially available in a number of countries. The characteristic symptoms of dengue are sudden-onset fever, headache typically located behind the eyes , muscle and joint pains, and a rash.
Dengue vaccine is a vaccine used to prevent dengue fever in humans. In March , the European Medicines Agency accepted the filing package for vaccine candidate TAK, which is designated for people not previously infected. There are several other vaccine candidates in development including live attenuated , inactivated , DNA and subunit vaccines.