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Essays on germline gene editing

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Date January 9, October 28, Medicine is at a turning point, on the cusp of major change as disruptive technologies such as gene, RNA, and cell therapies enable scientists to approach diseases in new ways. Progress in this field has been so rapid that the dialogue around potential ethical, societal, and safety issues is scrambling to catch up. This disconnect was brought into stark relief at the Second International Summit on Human Genome Editing , held in Hong Kong in November, when exciting updates about emerging therapies were eclipsed by a disturbing announcement. He Jiankui, a Chinese researcher, claimed that he had edited the genes of two human embryos, and that they had been brought to term.
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Gene-editing, religion and one scientist’s quest to reconcile the two | PBS NewsHour

On the one hand, reports of a rogue scientist, He Jiankui, who contravened the scientific and ethical norms that should guide the development of human genome editing reinforces the need for clarity about those norms and international monitoring of advances in the field. They lack any real enforcement power on their own, and have largely served to ensure that human genome editing research can continue, rather than promote reflection on whether we should edit the human germline in the first place. The organizing committee said no in an updated statement released last week. What intrigued me most about the summit was the continued emphasis on consensus — or something approaching it — as a condition of moving forward with clinical applications of germline editing. Alongside calls for consensus, summit organizers seemed to embrace the inevitability of germline editing trials. Several scientists shared research that would have clear clinical applications involving editing embryos or gametes. And yet, there is not consensus, even among summit panelists notably those from the humanities , that editing the human germline would ever be responsible.
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Nathaniel Rich, Ryan Phelan, Ben Novak

The problem related to the invention of editing the human germline gene is that it interferes with the original gene orientation. The ethical issue discussed in this journal is tampering with the human genes and the traits expected to be carried forward on to other future generations. This became a hazard to both the plants, that is environment and to human beings who feed on the animals that feed on plants containing the PCBs. Evident facts that make this invention an ethical dilemma was proven by a troop of Chinese scientists, who announced that the invention using Crispr to edit genes was held responsible for a disease that was inherited Ormond, The technology is thus believed to foster carrying forward of diseases that would rather have ended with one generation.
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Human germline engineering is the process by which the genome of an individual is edited in such a way that the change is inheritable. This is achieved through genetic alterations within the germ cells , or the reproductive cells, such as the egg and sperm. Human germline engineering is a type of genetic modification that directly manipulates the genome using molecular engineering techniques.
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